Document Type : Original Article
Authors
Department of Life Science, College of Education for Pure Sciences, Kirkuk University, Iraq
Abstract
Hyperlipidemia is a common disease that causes serious diseases and damages the kidneys due to increased oxidative stress. The Moringa plant was chosen because it contains antioxidants, including flavonoids, to reduce the level of lipids. The experiment was conducted at the Animal House/Veterinary College/Tikrit University, for a period from 10/1/2023 to 11/7/2024. Experimental rats: 40. Form 8 groups of 5 rats each. The healthy groups were fed a standard diet throughout the experiment, while the infected groups were fed a high-fat diet with 2% cholesterol throughout the experiment. The groups were divided as follows: 1 healthy control, 2 infected control fed a high-fat diet, 3 infected control and dosed with Moringa extract, 4 infected and dosed with atorvastatin, 5 infected control and dosed with the extract + the drug, 6 healthy control fed a standard diet and dosed with the extract. 7 were healthy and were dosed with the drug only, 8 were healthy and were dosed with the extract + the drug. The study was designed to determine the role of Moringa extract compared to the drug atorvastatin in improving risk factors for kidney disease resulting from hyperlipidemia. Biochemical results showed an increase in the levels of urea, creatinine, and uric acid in the hyperlipidemia group, and in the groups that were dosed with the extract and the drug, there was a significant decrease (P≥0.05). As for histological results, they showed histological disorders in the kidneys. The extract and drug were more effective in normalizing tissue lesions.
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